It is possible that "Cold" is a sign of, such as, chronic fatigue syndrome, rheumatoid arthritis, a collagen disease, and asthma. Here, the "Cold" is defined as condition, such as, fever, a cough, a feeling of fatigue, muscular pain, an arthritic pain, headache, a pain in the throat, and sleep disorder.A rash of the skin, conjunctivitis, and urethritis, may be seen. Sometimes, such condition prolongs or repeats, and then, protraction and chronic state.There is possibility of the sign of "an incurable disease".

Early symptoms present the condition like cold syndrome, fever, a feeling of fatigue, headache, a pain of a throat, a digestive symptom, a cough, a rash, etc.There is a difference individually. A dry cough is the early stages of development of symptoms, with progress of time, a cough becomes strong. In a seniority child or a youth, sometimes, it may become a moist cough in the later stage.

There are otitis media, arthritis, aseptic meningitis, encephalitis, hepatitis, pancreatitis, myocarditis, hemolytic anemia, Guillain-Barre' syndrome, a Stevens-Johnson syndrome, etc. as complications. It turns out that extrarespiratory symptoms could be seen, although there is almost no respiratory symptom.Mycoplasma is a pathogen of the infection which symptoms is shown with "cold" condition, and in pneumonia, it is the 3rd organism in pneumonia and is considered as 1st organism in acute bronchitis.

Since drug resistant mycoplasma has already appeared, the early diagnosis and therapy of the maycoplasma infectious diseases become more important. Furthermore, the feature of mycoplasma infection is the ability to become a cause of a variegated disease like diseases other than a lung, i.e., dermatitis, nephritis, arthritis and meningitis that presents neurological symptoms, or encephalitis at 25% of the infected humans.

Because the progress of a chronic inflammation disease is various and present broad range of symptoms, including an incurable disease (asthma, a rheumatic disease, a collagen disease, diseases of the nervous system, allergic disease), it is not easy to identified mycoplasma as the causative agent."Mycoplasma infectious diseases" is not only pneumonia, but also asthma, arthritis, nephritis, meningitis, encephalitis, arteritis, dermatitis, etc.. Further, it related to such as autoimmune diseases, rheumatic disease, a nervous system disorders, and inflammatory diseases.

It is very important to discover mycoplasma infectious diseases as early as possible, and to treat a cause of a disease curatively with medical treatment.