エムバイオテック


		Mycoplasma Infectious Diseases (MID) from acuteness to a chronic variegated condition, finally, incurable disease like condition.

		Mycoplasma is the 3rd causative organism of pneumonia and is considered as 1st of acute bronchitis. Mycoplasma is a pathogen of the infection which symptoms is shown as "cold“, community-acquired pneumonia. Cold is defined as condition, such as fever, a cough, a feeling of fatigue, muscular pain, an arthritic pain, headache, a pain in the throat, and sleep disorder. Such as a rash of the skin, conjunctivitis, and urethritis, may be seen. When such symptoms prolong or repeat. It may be the sign of an incurable disease such as chronic fatigue syndrome, rheumatoid arthritis, a collagen disease, asthma so on. MID not only includes pneumonia but also diseases such as asthma, arthritis, nephritis, meningitis, encephalitis, dermatitis, pancreatitis, hepatitis, and hematologic illnesses. The broader concept of MID encompasses acute to chronic phases with diverse symptoms. Therefore, it is often confusing and difficult to identify Mycoplasma-infected patients among those with incurable diseases, such as autoimmune diseases, rheumatic diseases, nervous system disorders, and hematological disorders.


		A Novel Therapeutic Strategy for Mycoplasma Infectious Diseases

		Distinction between an incurable disease and Mycoplasma Infectious Diseases is confusing, and difficult. It is important to identify mycoplasma infection at an early stage, and to treat a cause of the disease curatively. Since drug resistant mycoplasma has already appeared, the early diagnosis and therapy of the mycoplasma infectious diseases become more important. Regrettably, conventional diagnosis has only been available for pneumonia, although it is critical to identify MID at early stages for effective medical treatment. The cutting-edge technology has made it possible . If the cause of incurable disease comes to be know mycoplasma infection, there comes to be seen the medical treatment which can remove the original cause of it. Therefore, it is important to identify mycoplasma infection at an early stage, and to curatively treat the real cause of the disease.

		Precision Preventative Medicine for Mycoplasma Infectious Diseases
		New mycoplasma infection blood tests

		The new tests to measue the precice amounts of pecific antibodies against myoplasma-species specific glycolipid-antigens (1ml of serum)
		・Anti-Mycoplasma pneumonie-specific lipid-antigen IgM antibodies ・Anti-Mycoplasma pneumonie-specific lipid-antigen IgG antibodies ・Anti-Mycoplasma pneumonie-specific lipid-antigen IgA antibodies ・Anti-Mycoplasma fermentans-specific lipid-antigen IgM antibodies ・Anti-Mycoplasma fermentans-specific lipid-antigen IgG antibodies ・Anti-Mycoplasma fermentans-specific lipid-antigen IgA antibodies
		PCR method is problematic especially for chronic systemic infectious diseases. Because it is very difficult to detect mycoplasma by PCR constantly. "It is negative" does not mean "there is not mycoplasma". It crucially depend on how they take samples, where to take sample, and how to store the samples. There are also problems to see clinically. The cutting-edge technology based on the mycoplasma species-specific glycolipid-antigens, has made it possible to measure the amount of specific antibodies. The new technology provides a reliable marker to follow the state of Mycoplasma Infectious Diseases (MID) by monitoring antibody titer fluctuations from baseline. It therefore becomes possible to follow individual patients.
		Clinica and Hospitals Global Network

		Mycoplasma Infectious Diseases (MID)
		It is possible that "Cold" is a sign of, such as, chronic fatigue syndrome, rheumatoid arthritis, a collagen disease, and asthma. Here, the "Cold" is defined as condition, such as, fever, a cough, a feeling of fatigue, muscular pain, an arthritic pain, headache, a pain in the throat, and sleep disorder.A rash of the skin, conjunctivitis, and urethritis, may be seen. Sometimes, such condition prolongs or repeats, and then, protraction and chronic state.There is possibility of the sign of "an incurable disease". Early symptoms present the condition like cold syndrome, fever, a feeling of fatigue, headache, a pain of a throat, a digestive symptom, a cough, a rash, etc.There is a difference individually. A dry cough is the early stages of development of symptoms, with progress of time, a cough becomes strong. In a seniority child or a youth, sometimes, it may become a moist cough in the later stage. There are otitis media, arthritis, aseptic meningitis, encephalitis, hepatitis, pancreatitis, myocarditis, hemolytic anemia, Guillain-Barre' syndrome, a Stevens-Johnson syndrome, etc. as complications. It turns out that extrarespiratory symptoms could be seen, although there is almost no respiratory symptom.Mycoplasma is a pathogen of the infection which symptoms is shown with "cold" condition, and in pneumonia, it is the 3rd organism in pneumonia and is considered as 1st organism in acute bronchitis. Since drug resistant mycoplasma has already appeared, the early diagnosis and therapy of the maycoplasma infectious diseases become more important. Furthermore, the feature of mycoplasma infection is the ability to become a cause of a variegated disease like diseases other than a lung, i.e., dermatitis, nephritis, arthritis and meningitis that presents neurological symptoms, or encephalitis at 25% of the infected humans. Because the progress of a chronic inflammation disease is various and present broad range of symptoms, including an incurable disease (asthma, a rheumatic disease, a collagen disease, diseases of the nervous system, allergic disease), it is not easy to identified mycoplasma as the causative agent."Mycoplasma infectious diseases" is not only pneumonia, but also asthma, arthritis, nephritis, meningitis, encephalitis, arteritis, dermatitis, etc.. Further, it related to such as autoimmune diseases, rheumatic disease, a nervous system disorders, and inflammatory diseases. It is very important to discover mycoplasma infectious diseases as early as possible, and to treat a cause of a disease curatively with medical treatment.

		Chronic fatigue syndrome and mycoplasma infection
		Myalgic Encephalomyelitis, which includes CFS, is classified as a neurological disease in the World Health Organization’s International Classification of Diseases (ICD). Symptoms of CFS include post-exertional malaise; unrefreshing sleep; widespread muscle and joint pain; sore throat; headaches of a type not previously experienced; cognitive difficulties; chronic, often severe, mental and physical exhaustion; and other characteristic symptoms in a previously healthy and active person. Persons with CFS may report additional symptoms including muscle weakness, increased sensitivity to light, sounds and smells, orthostatic intolerance, digestive disturbances, depression, and cardiac and respiratory problems.
		Rheumatic disease and mycoplasma infection
		Reactive arthritis is classified as an autoimmune condition that develops in response to an infection in another part of the body (cross-reactivity). Coming into contact with bacteria and developing an infection can trigger the disease. Usually, by the time the patient presents with symptoms, oftentimes the "trigger" infection has been cured or is in remission in chronic cases, thus making determination of the initial cause difficult. The arthritis often is coupled with other characteristic symptoms; this is called Reiter's Syndrome or Reiter's arthritis. The manifestations of Reiter's Syndrome include the following triad of symptoms: an inflammatory arthritis of large joints, inflammation of the eyes in the form of conjunctivitis or uveitis, and urethritis in men or cervicitis in women.
		Cardiovascular diseases and mycoplasma infection
		Vasculitis refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis. Vasculitis is primarily due to leukocyte migration and resultant damage.
		Connective tissue disease and mycoplasma infection
		A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs. Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune system that is directed against one's own body tissues (autoimmunity).
		Asthma and mycoplasma infection
		Asthma is the common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include wheezing, coughing, chest tightness, and shortness of breath. Asthma is caused by environmental and genetic factors. These factors influence how severe asthma is and how well it responds to medication. Asthma may also be classified as atopic (extrinsic) or non-atopic (intrinsic). Although asthma is a chronic obstructive condition, it is not considered as a part of chronic obstructive pulmonary disease as this term refers specifically to combinations of disease that are irreversible such as bronchiectasis, chronic bronchitis, and emphysema. Unlike these diseases, the airway obstruction in asthma is usually reversible. The strongest risk factor for developing asthma is a history of atopic disease. The term "atopy" was coined to describe this triad of atopic eczema, allergic rhinitis and asthma.
		Neurological disorders and mycoplasma infection
		M. pneumoniae was strongly implicated as the probable etiologic agent in 1-10% children with acute encephalitis. M. pneumoniae has been implicated as a cause of immunemediated neurologic syndromes, including ADEM, transversemyelitis, and Guillain-Barre´ syndrome
		Myocarditis and mycoplasma infection

		Nephritis and mycoplasma infection

		Urethritis, prostatitis and mycoplasma infection

		Hypoimmunity and mycoplasma infection

		Anaemia and mycoplasma infection

		Dermatitis and mycoplasma infection


		Comprehensive Precision Medicine

		Vaccines for Mycoplasma Infectious Diseases (MID)
		Antibiotics-resistant mycoplasma has emerged, therefore the development of vaccine for Mycoplasma Infectious Diseases becomes more important for treatment, preventive medicine, social welfare. Molecular mechanisms of lipid-antigen recognition are important in the frontier of immunology. Possible pathogeneses of autoimmune diseases and tumours now include infections with microorganisms. Therefore, the role of vaccines is increasingly important, as advancing technology has now broadened the targets of vaccination to include a greater number of infectious diseases, tumours, chronic infections, autoimmune diseases and allergies. In order to prevent infectious diseases through vaccination, it is important to identify specific antigens which often exist in the cell membrane and capsule and also become the centre of host-pathogen interactions. Structural analysis of lipid-antigens is critical for understanding the mechanisms of molecular interactions involved in the pathogenesis of immune abnormalities, and for devising strategies surrounding immune system regulation and drug discovery.

Asthma and mycoplasma infection

Neurological disorders and mycoplasma infection