エムバイオテック


			Cardiovascular diseases

			Cardiovascular diseases and Mycoplasma infectious diseases
			Vasculitis Vasculitis refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis. Vasculitis is primarily due to leukocyte migration and resultant damage. According to the size of the vessel affected, vasculitis can be classified into: Large vessel: Behçet's syndrome, Polymyalgia rheumatica, Takayasu's arteritis, Temporal arteritis; Medium vessel: Buerger's disease, Cutaneous vasculitis, Kawasaki disease, Polyarteritis nodosa; Small vessel: Churg–Strauss syndrome, Cutaneous vasculitis, Henoch–Schönlein purpura, Microscopic polyangiitis, Wegener's granulomatosis. Symptoms Petechia and purpura on the low limb due to medication induced vasculitis. General symptoms: Fever, weight loss Skin: Palpable purpura, livedo reticularis Muscles and joints: Myalgia or myositis, arthralgia or arthritis Nervous system: Mononeuritis multiplex, headache, stroke, tinnitus, reduced visual acuity, acute visual loss Heart and arteries: Myocardial infarction, hypertension, gangrene Respiratory tract: Nose bleeds, bloody cough, lung infiltrates GI tract: Abdominal pain, bloody stool, perforations Kidneys: Glomerulonephritis Arteritis and mycoplasma infection P. Elling, A.T. Olsson, H. Elling, Synchronous variations of the incidence of temporal arteritis and polymyalgia rheumatica in different regions of Denmark; association with epidemics of Mycoplasma pneumoniae infection, J Rheumatol 23 (1996) 112-119. Henoch-Schönlein purpura and mycoplasma infection HSP is a systemic vasculitis (inflammation of blood vessels) and is characterized by deposition of immune complexes containing the antibody IgA. Signs and symptoms Purpura, arthritis and abdominal pain are known as the "classic triad" of Henoch–Schönlein purpura. Forty percent have evidence of kidney involvement, mainly in the form of hematuria (blood in the urine), but only a quarter will have this in sufficient quantities to be noticeable without laboratory tests. More than half also have proteinuria (protein in the urine), which in one eighth is severe enough to cause nephrotic syndrome. Problems in other organs, such as the central nervous system (brain and spinal cord) and lungs may occur, but is much less common than in the skin, bowel and kidneys. Henoch-Schönlein purpura is a small-vessel vasculitis in which complexes of immunoglobulin A (IgA) and complement component 3 (C3) are deposited on arterioles, capillaries, and venules. As with IgA nephropathy, serum levels of IgA are high in HSP. HSP occurs more often in children than in adults, and usually follows an upper respiratory tract infection. HSP can develop after infections with streptococci (β-haemolytic, Lancefield group A), hepatitis B, herpes simplex virus, parvovirus B19, Coxsackievirus, adenovirus, Helicobacter pylori, measles, mumps, rubella, Mycoplasma.